- 专利标题： MESOTHELIN-TARGETED CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF
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申请号： EP22186683.3申请日： 2015-06-05
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公开(公告)号： EP4166148A1公开(公告)日： 2023-04-19
- 发明人: ADUSUMILLI, Prasad, S. , SADELAIN, Michel , DIMITROV, Dimiter, S , FENG, Yang
- 申请人： Memorial Sloan-Kettering Cancer Center , The United States of America, as represented by The Secretary, Department of Health and Human Services
- 申请人地址： US New York, NY 10065 1275 York Avenue; US Bethesda, Maryland 20892-7660 Office of Technology Transfer National Institutes of Health 6011 Executive Boulevard Suite 325 MSC 7660
- 代理机构： Barker Brettell LLP
- 优先权： US201462008851 P 20140606
- 主分类号： A61K35/00
- IPC分类号： A61K35/00 ; A61K38/00 ; A61K39/00 ; C07K14/47 ; C07K14/705 ; C07K14/725 ; C07K16/28 ; C07K16/30 ; A61P1/18 ; A61P29/00 ; A61P31/00 ; A61P35/00 ; A61P37/04 ; A61P37/06 ; A61P43/00
摘要：
The presently disclosed subject matter provides for methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to chimeric antigen receptors (CARs) that specifically target human mesothelin, and immunoresponsive cells comprising such CARs. The presently disclosed mesothelin-targeted CARs have enhanced immune-activating properties, including anti-tumor activity.
To be accompanied, when published, by Figure 1 of the drawings.
To be accompanied, when published, by Figure 1 of the drawings.
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