- 专利标题: PREPARATION METHOD FOR OXETANE-2-METHYLAMINE
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申请号: EP21847921.0申请日: 2021-11-12
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公开(公告)号: EP4194446A1公开(公告)日: 2023-06-14
- 发明人: TIAN, Yong , YANG, Jun , XUE, Duoqing , WU, Yong , CHEN, Lihuang
- 申请人: ACCELA CHEMBIO CO., LTD.
- 申请人地址: CN Shanghai 201203 Room 206B, Building 1, No. 185 Zhangjiang Road China (Shanghai) Pilot Free Trade Zone Pudong New Area
- 代理机构: Tergau & Walkenhorst Patentanwälte PartGmbB
- 优先权: CN202111219345 20211020
- 国际公布: WO2023065434 20230427
- 主分类号: C07D305/06
- IPC分类号: C07D305/06 ; C07D211/40
摘要:
Disclosed is a method for preparing oxetan-2-ylmethanamine, which belongs to the field of organic synthesis. [2-(1-ethoxyethoxy)methyl]propylene oxide is used as an initial raw material, and reacted in the presence of potassium tert-butoxide and trimethylsulfoxonium iodide; the resulting product is reacted with a sulfonyl compound and triethylamine; the resulting product is reacted with a compound of phthalimide; the resulting product is reacted with an amino group-containing compound, to obtain oxetan-2-ylmethanamine. The method according to the disclosure allows for an overall yield of not less than 30% in scale-up production (kilogram level), which is higher. Moreover, compared with the traditional method for preparing oxetan-2-ylmethanamine, a palladium-carbon catalytic hydrogenation step is not required, and dangerous chemical-sodium azide is not required in the method according to the disclosure. Thus, the method has high safety, low production cost, simple operations, and thereby is suitable for industrial production.
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