An LED flexible wire light in parallel-series connection comprises: first flexible wire, second flexible wire, third flexible wire, and a plurality of SMD LED groups; said first flexible wire, said second flexible wire and said third flexible wire are enclosed by non-conductive material without any conduction each other; said plurality of SMD LED groups are numbered as first SMD LED group, second SMD LED group, ..., Nth SMD LED group; said SMD LED groups with odd numbers are odd SMD LED groups, said SMD LED groups with even numbers are even SMD LED groups; said plurality of SMD LED groups are electrically connected between said first flexible wire and said second flexible wire in order of said SMD LED groups' number; said third flexible wire is the cathode of said LED flexible wire light, and said first flexible wire is the anode of said LED flexible wire light. The manual welding connection is reduced. The efficiency is higher to down the manufacture cost. And the resistance to tension of lights in parallel-series connection is enhanced. Thus, the LED flexible wire light in series-parallel connection can be manufactured in mass.