- 专利标题: APPLICATION OF ?-ASARONE IN PREPARATION OF MEDICINE FOR PREVENTING OR TREATING HEMORRHAGIC STROKE
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申请号: EP21950502.1申请日: 2021-07-22
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公开(公告)号: EP4205734A1公开(公告)日: 2023-07-05
- 发明人: MAO, Shengjun , GAO, Xiaofeng , LUO, Lijun , LI, Rui , ZHANG, Jian , YANG, Peng , ZHANG, Di , LIU, Qi , YANG, Huiyuan
- 申请人: Sichuan University
- 申请人地址: CN Chengdu, Sichuan 610065 No. 24 South Section 1 Yihuan Road
- 代理机构: Dehns
- 国际公布: WO2023000247 20230126
- 主分类号: A61K31/09
- IPC分类号: A61K31/09 ; A61K9/107 ; A61P7/04
摘要:
The present invention provides an application of α-asarone in the preparation of a medicine for preventing or treating hemorrhagic strokes. α-asarone has the structure shown in formula I, and may significantly improve short-term neurological deficits and long-term learning and memory functions of model rats, reduce cerebral edema, improve the permeability of the blood-brain barrier, and prevent or mitigate the atrophy of brain tissue during a recovery period. α-asarone has a precise therapeutic effect on animal models of hemorrhagic stroke without obvious toxic side effects, and is expected to have great application prospects as a medicine for preventing/treating hemorrhagic strokes.
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