发明公开
- 专利标题： SALT OF NUCLEOSIDE ANALOG AND CRYSTAL FORM THEREOF, PHARMACEUTICAL COMPOSITION AND USE
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申请号： EP21885029.5申请日： 2021-10-21
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公开(公告)号： EP4234557A1公开(公告)日： 2023-08-30
- 发明人: SHEN, Jingshan , XIE, Yuanchao , ZHANG, Leike , XIAO, Gengfu , WANG, Zhen , JIANG, Hualiang , XU, Huaqiang , HU, Tianwen , TIAN, Guanghui
- 申请人： Vigonvita Life Sciences Co., Ltd. , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Wuhan Institute Of Virology, Chinese Academy of Sciences
- 申请人地址： CN Suzhou, Jiangsu 215123 8th Floor, Building A 108 Yuxin Road Suzhou Industrial Park; CN Pudong, Shanghai 201203 555 Zu Chong Zhi Road Zhang Jiang; CN Wuhan, Hubei 430071 No.44 Xiaohongshan Middle Area Shuiguohu Street Wuchang District
- 代理机构： Algemeen Octrooi- en Merkenbureau B.V.
- 优先权： CN202011505962 20201218
- 国际公布： WO2022089302 20220505
- 主分类号： C07D487/04
- IPC分类号： C07D487/04 ; A61K31/53 ; A61P31/14
摘要：
The present disclosure pertains to the technical field of medicine, and relates to salt of nucleoside analog, and crystal form, pharmaceutical composition and use thereof. Specifically, the salt of nucleoside analog has a structure shown in formula I, wherein X is hydrogen or deuterium; Y is an acid, preferably hydrogen bromide, hydrogen chloride, nitric acid, methanesulfonic acid or maleic acid, n is 0.5 to 2, preferably 1. When X is hydrogen or deuterium, Y is hydrogen bromide, and n is 1, the salt of the nucleoside analog exists in the form of a crystal with crystal form I or crystal form A or exists in an amorphous form, which has good appearance as solid material, high stability, good solubility, low hygroscopicity, etc., and can be used in the preparation of medicaments for the treatment and/or alleviation of related diseases caused by viruses (especially SARS-CoV-2).
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