- 专利标题： PROGRAMMED CELL DEATH 1 (PD1) SPECIFIC NUCLEASES
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申请号： EP23162123.6申请日： 2019-09-18
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公开(公告)号： EP4234570A2公开(公告)日： 2023-08-30
- 发明人: MILLER, Jeffrey C. , REBAR, Edward J. , ZHANG, Lei
- 申请人： Sangamo Therapeutics, Inc.
- 申请人地址： US Brisbane, CA 94005 7000 Marina Blvd
- 代理机构： Carpmaels & Ransford LLP
- 优先权： US201862732674 P 20180918
- 主分类号： C07K14/05
- IPC分类号： C07K14/05 ; C12N9/22
摘要：
Described herein are engineered nucleases specific for PD1 gene target sites, the nucleases comprising mutations in the cleavage domain ( e.g., Fok I or homologue thereof) and/or DNA binding domain (zinc finger protein, TALE, single guide RNA) such that on-target specificity for PD1 gene target sites is increased.
公开/授权文献
- EP4234570A3 PROGRAMMED CELL DEATH 1 (PD1) SPECIFIC NUCLEASES 公开/授权日：2023-12-13
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