A mobile device may be configured to perform concurrent Satellite Positioning System (SPS) operation and wireless communications when uplink signals transmitted by the mobile device interferes with the reception of SPS signals in one or more frequency bands. The mobile device may determine if the SPS receiver has already acquired SPS signals and is in a tracking state. If the SPS receiver is not in a tracking state, an SPS acquisition procedure is initiated before the wireless communication session is initiated. The SPS acquisition procedure is performed until the SPS receiver reaches a tracking state, or until a timeout is reached. Once the SPS receiver is in a tracking state, the wireless communication session may be initiated, during which the SPS receiver is controlled, e.g., to perform signal blanking, measurement exclusion, or disable SPS reception, to mitigate interference with SPS signals.