Provided are physical-layer resource mapping methods and devices, UE and a base station. The method includes: during multiplexing transmission of hybrid automatic repeat request acknowledgement (HARQ ACK) information and uplink data, determining a starting position and frequency-domain offset of an HARQ-ACK modulation symbols mapped to a physical-layer resource, the frequency-domain offset being each of frequency-domain offsets of resource elements (REs) that different HARQ-ACK modulation symbols are mapped to; and mapping each HARQ-ACK modulation symbol to the corresponding RE according to the starting position and the frequency-domain offset. Accordingly, the HARQ-ACK modulation symbols may be uniformly distributed to as many orthogonal frequency division multiplexing (OFDM) symbols as possible preferably in a frequency domain in a manner of time domain first, and uplink data transmission performance reduction caused by concentrated distribution of the HARQ-ACK modulation symbol on one or more OFDM symbols can be avoided.