An intelligent 3D printing and additive manufacturing construction system comprising a printing machine connected to an external pumping device configured to feed a printing head of the printing machine with fresh concrete or mortar that is extruded through an extrusion nozzle of the printing head according to a layer pattern predefined in a digital file executable by a processor of the printing machine; and wherein, in addition, the layers of the predefined pattern are applied continuously until the geometry configured in the digital file is printed, wherein the printing machine is configured as a mechanical system with a Cartesian configuration (X-Y-Z), having a continuous and modular Y axis, to allow the printing range to be adapted to constructions of different dimensions using the same printer. The equipment will be equipped with machine vision and artificial intelligence equipment to promote the autonomy and quality of the printing process.