This application discloses a route processing method and a network device. The network device obtains a route prefix and autonomous system information associated with the obtained route prefix, where the associated autonomous system information includes to-be-verified autonomous system information. The network device verifies whether there is a match item in a route origin information base, where the match item includes the obtained route prefix and the to-be-verified autonomous system information; and determines, based on a verification result, whether to send the obtained route prefix. The network device verifies the autonomous system information associated with the to-be-sent route prefix before sending the route prefix. This reduces a possibility that the network device sends route information carrying incorrect autonomous system information, and reduces a possibility of causing an abnormal network flow direction.