- 专利标题: METHODS OF TREATING FABRY PATIENTS HAVING RENAL IMPAIRMENT
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申请号: EP23219933.1申请日: 2018-05-30
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公开(公告)号: EP4327869A3公开(公告)日: 2024-05-22
- 发明人: Castelli, Jeff
- 申请人: Amicus Therapeutics, Inc.
- 申请人地址: US Philadelphia, PA 19104 3675 Market Street
- 专利权人: Amicus Therapeutics, Inc.
- 当前专利权人: Amicus Therapeutics, Inc.
- 当前专利权人地址: US Philadelphia, PA 19104 3675 Market Street
- 代理机构: Hoffmann Eitle
- 优先权: US 201762512458 P 2017.05.30
- 分案原申请号: 23189734.9 2023.08.04;18733415.6 2018.05.30
- 主分类号: A61K31/445
- IPC分类号: A61K31/445 ; A61P13/12
摘要:
Provided are methods for treatment of Fabry disease in a patient having renal impairment and/or elevated proteinuria. Certain methods comprise administering to the patient about 100 to about 150 mg free base equivalent of migalastat or salt thereof at a frequency of once every other day. Certain methods also provide for the stabilization of renal function, reducing left ventricular mass index, reducing plasma globotriaosylsphingosine and/or increasing α-galactosidase A activity in the patient.
公开/授权文献
- EP4327869A2 METHODS OF TREATING FABRY PATIENTS HAVING RENAL IMPAIRMENT 公开/授权日:2024-02-28
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