This application relates to the field of satellite communication, and discloses a multi-frame integrated transmission method in a BeiDou communication system and a related apparatus. Therefore, in the BeiDou communication system, a transmit end may negotiate an acknowledgment mode with a receive end based on a total frame quantity field and a frame sequence number field in frame header information of a data frame. In this way, when the transmit end negotiates the acknowledgment mode with the receive end, additional frame header cell overheads and control signaling overheads may not be required.