- 专利标题： FORMULATION FOR ANTI-ALPHA4BETA7 ANTIBODY
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申请号： EP24167556.0申请日： 2012-05-02
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公开(公告)号： EP4378484A3公开(公告)日： 2024-09-04
- 发明人: DILUZIO, Willow , TRUONG, Nobel T. , VARGA, Csanad M. , PALANIAPPAN, Vaithianathan , BROWN, Jason , FOX, Irving H. , SCHOLZ, Catherine
- 申请人： Millennium Pharmaceuticals, Inc.
- 申请人地址： US Cambridge, MA 02139 40 Landsdowne Street
- 专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人地址： US Cambridge, MA 02139 40 Landsdowne Street
- 代理机构： Hoffmann Eitle
- 优先权： US 1161481533P 2011.05.02
- 分案原申请号： 18150968.8 2018.01.10;17180246.5 2017.07.07;12721093.8 2012.05.02
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61K47/18 ; A61K39/00 ; A61P1/00 ; A61K39/395 ; A61K9/19 ; A61K47/26 ; A61K9/00 ; A61P1/04 ; A61P29/00 ; A61P37/00 ; A61P37/02
摘要：
Antibody formulations are described comprising a mixture of a non-reducing sugar, an anti-α4β7 antibody and at least one amino acid. The disclosed formulations have improved stability, reduced aggregate formation, and may retard degradation of the anti-α4β7 antibody therein or exhibit any combinations thereof. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 antibody in vivo.
公开/授权文献
- EP4378484A2 FORMULATION FOR ANTI-ALPHA4BETA7 ANTIBODY 公开/授权日：2024-06-05
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