The present disclosure is directed to prediction and assistive techniques using a multi-region graphical keyboard interface. In particular, the system can present, on a display of a computing device, a graphical keyboard having a plurality of key regions. The plurality of key regions can include a first key region having a first set of keys and a second key region having a second set of keys. Additionally, the system can receive a first input selecting a first selected region from the plurality of key regions. Moreover, the system can determine, based at least in part on the first input, a first suggestion and a second suggestion. Furthermore, in response to the first input, the system can present, on the display of the computing device, an updated graphical keyboard having the plurality of key regions and a suggestion region. The suggestion region includes the first suggestion and the second suggestion.