- 专利标题： UREA COMPOUND CONTAINING 2-HETEROAROMATIC RING SUBSTITUTION, PREPARATION METHOD THEREFOR AND USE THEREOF
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申请号： EP22857522.1申请日： 2022-07-26
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公开(公告)号： EP4389736A1公开(公告)日： 2024-06-26
- 发明人: HU, Youhong , CHEN, Yi , XIE, Zhicheng , DING, Jian , LI, Xin , FANG, Yanfen , SHEN, Qianqian
- 申请人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 申请人地址： CN Pudong, Shanghai 201203 555 Zu Chong Zhi Road Zhang Jiang
- 专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 当前专利权人： Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 当前专利权人地址： CN Pudong, Shanghai 201203 555 Zu Chong Zhi Road Zhang Jiang
- 代理机构： Grünecker Patent- und Rechtsanwälte PartG mbB
- 优先权： CN 2110936628 2021.08.16
- 国际申请： CN2022107742 2022.07.26
- 国际公布： WO2023020209 2023.02.23
- 主分类号： C07D213/75
- IPC分类号： C07D213/75 ; A61P35/00 ; A61K31/506
摘要：
The present invention relates to a urea compound containing 2-heteroaromatic ring substitution represented by formula (I), its enantiomers, diastereomers, racemates or mixtures thereof, or pharmaceutically acceptable salts thereof, solvate, metabolite or prodrug. The compound of formula (I) of the present invention has inhibitory activity against CDK9, and representative compounds have significant anti-tumor activity against CDK9 high-expressing tumor cells. Representative compounds have plasma stability and low clearance.
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