- 专利标题： GFRAL-ANTAGONISTIC ANTIBODY HAVING IMPROVED AFFINITY, AND USE THEREOF
-
申请号： EP22873130.3申请日： 2022-09-05
-
公开(公告)号： EP4406972A1公开(公告)日： 2024-07-31
- 发明人: YEA, Kyung Moo , LEE, Beom Yong , JEONG, Jong Won
- 申请人： Daegu Gyeongbuk Institute Of Science and Technology
- 申请人地址： KR Daegu 42988 333, Techno Jungang-daero, Hyeonpung-eup, Dalseong-gun,
- 专利权人： Daegu Gyeongbuk Institute Of Science and Technology
- 当前专利权人： Daegu Gyeongbuk Institute Of Science and Technology
- 当前专利权人地址： KR Daegu 42988 333, Techno Jungang-daero, Hyeonpung-eup, Dalseong-gun,
- 代理机构： Roos, Peter
- 优先权： KR 210126371 2021.09.24
- 国际申请： KR2022013279 2022.09.05
- 国际公布： WO2023048425 2023.03.30
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; A61P1/14 ; A61K39/00
摘要：
The present invention relates to a GFRAL-antagonistic antibody having improved affinity and a use thereof, and more particularly, the present invention relates to an anti-GFRAL antibody having improved affinity, comprising a heavy chain CDR and a light chain CDR of specific sequences, or an antigen-binding fragment thereof. The anti-GFRAL antibody having improved affinity exhibits higher binding ability to a GFRAL protein than a conventional anti-GFRAL antibody, and thus is expected to be effectively used for improving or treating cancer-related anorexia or cachexia syndrome and side effects of chemotherapy anticancer drugs.
信息查询
