A refrigerator having an inclined drain pipe disposed at a lower portion of the refrigerator comprises: a box body; a storage chamber is defined in the box body, a refrigeration cavity used for arranging an evaporator is formed in the bottom of the storage chamber, a heat dissipation machine compartment is formed in the box body at the lower rear of the refrigeration cavity, and a front wall of the heat dissipation machine compartment extends obliquely upwards from front to back from the middle of a box body bottom plate; an evaporation dish is arranged in the heat dissipation machine compartment; a drain pipe extends obliquely downwards from front to back from the bottom of the refrigeration cavity, passes through the front wall of the heat dissipation machine compartment and then further extends to the evaporation dish, so that defrosted water in the refrigeration cavity is discharged to the evaporation dish; a water pipe securing member is arranged at the position where the drain pipe passes through the front wall, and is used for securing the drain pipe; the water pipe securing member has a first securing face, and the first securing face is used for abutting the front wall of the heat dissipation machine compartment. The present solution can avoid foam overflow and improve fastening reliability.