- 专利标题： DESIGNED SYNZIP PROTEIN DOMAINS FOR GENERATING ARTIFICIAL NONRIBOSOMAL PEPTIDE SYNTHETASES AND HYBRIDS THEREOF
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申请号： EP23160049.5申请日： 2023-03-03
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公开(公告)号： EP4424820A1公开(公告)日： 2024-09-04
- 发明人: The designation of the inventor has not yet been filed
- 申请人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. , Myria Biosciences AG
- 申请人地址： DE 80539 München Hofgartenstraße 8
- 专利权人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.,Myria Biosciences AG
- 当前专利权人： Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.,Myria Biosciences AG
- 当前专利权人地址： DE 80539 München Hofgartenstraße 8
- 代理机构： Kuttenkeuler, David
- 主分类号： C12N9/00
- IPC分类号： C12N9/00
摘要：
The invention is based on newly derivatized protein interaction adaptor protein sequences based on SYNZIP protein domains. The improved SYNZIP domain variants of the invention were designed to be suitable for interconnecting domains of non-ribosomal peptide synthetases (NRPS) or domains of polyketide synthases (PKS), such as for generating NRPS-PKS hybrid complexes. The invention provides the SYNZIP derivative sequences, NRPS domains containing them, NRPS domain libraries thereof, as well as methods for the production and use in peptide design, screening and production.
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