A computing node in a multi-node computing system includes a local memory, at least one processor, and an access library. The at least one processor runs an operating system that runs a distributed application in a virtual address space. The application includes a process that generates a first memory access request that includes a first virtual address. The access library is responsive to the first memory access request by: converting the first virtual address into a first physical address, accessing the local memory based on the first physical address including a first indication that the first memory access request is for the local memory, and accessing a global access tuple table based on the first physical address including a second indication that the first memory access request is for memory located on a second computing node of the multi-node computing system that is remotely located from the computing node.