A tool for fabrication of a thermoplastic panel includes a sealed vessel, a membrane and a heater. The sealed vessel defines a volume. The sealed vessel includes first and second fluid ports. The membrane is disposed within the volume to define first and second chambers. The first chamber receives a skin and a core of the thermoplastic panel. The first chamber selectively applies a first fluidic pressure to the skin and the core in response to receiving a first fluid via the first fluid port. The membrane abuts a major surface of the thermoplastic panel. The second chamber selectively applies a second fluidic pressure to the membrane in response to receiving a second fluid via the second fluid port. The heater selectively directs heat toward the first chamber. A method for fabrication of the thermoplastic panel is provided. Various examples of thermoplastic panels are also provided.