- 专利标题： FORMULATION FOR ANTI-ALPHA4BETA7 ANTIBODY
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申请号： EP24167555.2申请日： 2012-05-02
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公开(公告)号： EP4438625A2公开(公告)日： 2024-10-02
- 发明人: DILUZIO, Willow , NGUYEN, Phuong M. , VARGA, Csanad M. , PALANIAPPAN, Vaithianathan , BROWN, Jason , FOX, Irving H. , SCHOLZ, Catherine , JENKINS, Erica Helen , ROSARIO, Maria
- 申请人： Millennium Pharmaceuticals, Inc.
- 申请人地址： US Cambridge, MA 02139 40 Landsdowne Street
- 专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人： Millennium Pharmaceuticals, Inc.
- 当前专利权人地址： US Cambridge, MA 02139 40 Landsdowne Street
- 代理机构： Hoffmann Eitle
- 优先权： US 1161481522P 2011.05.02
- 分案原申请号： 17180247.3 2017.07.07;12722973.0 2012.05.02
- 主分类号： C07K16/28
- IPC分类号： C07K16/28
摘要：
Antibody formulations are described comprising a mixture of an anti-α4β7 antibody, an antioxidant or chelator, and at least one free amino acid. The disclosed formulations may have improved stability, reduced aggregate formation, or both. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 antibody in vivo.
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