- 专利标题： NITROGEN-CONTAINING HETEROCYCLIC COMPOUND HAVING NRF2 ACTIVATION EFFECT
-
申请号： EP23737317.0申请日： 2023-01-06
-
公开(公告)号： EP4446312A1公开(公告)日： 2024-10-16
- 发明人: KIMBARA Atsushi , HARADA Takeo , KOMIYAMA Susumu , OKUYAMA Mizuki , OHTAKE Yoshihito , MURATA Yoshihisa , SAITO Rie
- 申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA
- 申请人地址： JP Tokyo 115-8543 5-1, 5-chome Ukima Kita-ku
- 代理机构： Vossius & Partner Patentanwälte Rechtsanwälte mbB
- 优先权： JP2022001804 20220107
- 国际公布： WO2023132369 20230713
- 主分类号： C07D217/06
- IPC分类号： C07D217/06 ; A61K31/472 ; A61K31/4725 ; A61K31/5377 ; A61K31/5386 ; A61K31/541 ; A61K31/5415 ; A61K31/551 ; A61P11/00 ; A61P13/12 ; A61P25/00 ; A61P43/00 ; C07D237/32 ; C07D265/14 ; C07D279/08 ; C07D401/10 ; C07D401/14 ; C07D403/10 ; C07D413/10 ; C07D413/12 ; C07D417/10
摘要：
Provided is a low-molecular compound or a salt thereof, or a solvate thereof which has the ability to activate Nrf2.
The present invention provides a compound represented by the formula (1) or a salt thereof, or a solvate thereof, wherein X a1 is CR a1 or N, X a3 is CR a3 or N, R a1 , R a2 and R a3 are each independently selected from the group consisting of hydrogen, halogen and C 1 -C 6 alkoxy, X b1 , X b2 and X b3 are each independently selected from the group consisting of CH 2 , O, NH, S and C=O, Y is C 6 -C lO aryl optionally having a substituent or 5- to 10-membered heteroaryl optionally having a substituent, and Z is C 6 -C lO aryl optionally having a substituent, 5- to 10-membered heteroaryl optionally having a substituent or C 1 -C 6 alkyl optionally having a substituent.
The present invention provides a compound represented by the formula (1) or a salt thereof, or a solvate thereof, wherein X a1 is CR a1 or N, X a3 is CR a3 or N, R a1 , R a2 and R a3 are each independently selected from the group consisting of hydrogen, halogen and C 1 -C 6 alkoxy, X b1 , X b2 and X b3 are each independently selected from the group consisting of CH 2 , O, NH, S and C=O, Y is C 6 -C lO aryl optionally having a substituent or 5- to 10-membered heteroaryl optionally having a substituent, and Z is C 6 -C lO aryl optionally having a substituent, 5- to 10-membered heteroaryl optionally having a substituent or C 1 -C 6 alkyl optionally having a substituent.
信息查询
