Provided are a method and apparatus for generating an image reconstruction model and an image reconstruction method and apparatus using the image reconstruction model. The image reconstruction apparatus extracts, through an encoder configured to extract a structure and a texture, a structure and a texture of each of a first medical image and a second medical image and generates, through a decoder configured to reconstruct an image based on a structure and a texture, a third medical image in which the texture of the second medical image is combined with the structure of the first medical image.