There in a method of treating cancer, the composition for use in such methods, (i) and one compound of xanthenone acetic acid group compound, act on compounds and biochemical pathways that regulate (ii) TNF production TNF and process comprising at least one compound sequentially or step of administering simultaneously selected synthesized from compounds which produce, above and (i) a combination of (ii), an acceptable pharmaceutical carrier and by / or compositions comprising with excipients.