- 专利标题: Methods and compositions for isolating metastatic cancer cells, as well as its use in the measurement of the metastatic potential of cancer
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申请号: JP2002525831申请日: 2001-08-28
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公开(公告)号: JP2004522937A公开(公告)日: 2004-07-29
- 发明人: チェン,ウェン−ティエン
- 申请人: ザ・リサーチ・ファウンデーション・オブ・ステイト・ユニヴァーシティ・オブ・ニューヨーク
- 专利权人: ザ・リサーチ・ファウンデーション・オブ・ステイト・ユニヴァーシティ・オブ・ニューヨーク
- 当前专利权人: ザ・リサーチ・ファウンデーション・オブ・ステイト・ユニヴァーシティ・オブ・ニューヨーク
- 优先权: US23151700 2000-09-09
- 主分类号: G01N33/48
- IPC分类号: G01N33/48 ; A61K35/12 ; A61K35/28 ; A61M1/02 ; A61M1/36 ; C12N5/00 ; C12N5/09 ; C12N15/09 ; C12N15/113 ; C12Q1/02 ; C12Q1/68 ; G01N21/77 ; G01N21/78 ; G01N33/15 ; G01N33/50 ; G01N33/569 ; G01N33/574 ; G01N33/58
摘要:
The present invention relates to novel methods and compositions for detection and isolation of cancer cells with metastatic potential. The invention further relates to assays for measuring the metastatic potential of such cancer cells and drug screening assays for the identification of agents having anti-metastatic potential. The present invention further provides methods and compositions for inhibiting the metastatic potential of cancer cells by modulating the activity of serine integral membrane proteases [(SIMP) consisting of seprase and dipetidyl peptidase IV (DPPIV)] expressed on the surface of metastasizing cancer cells.
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