发明专利
- 专利标题： Nucleic acid-containing nano particle
- 专利标题（中）： 含有核酸的纳米颗粒
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申请号： JP2004205842申请日： 2004-07-13
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公开(公告)号： JP2006028041A公开(公告)日： 2006-02-02
- 发明人: ISHIHARA TSUTOMU , HIGAKI MEGUMI , MURAKAMI YASUKO , MIZUSHIMA YUTAKA
- 申请人： Ltt Bio-Pharma Co Ltd , 株式会社Lttバイオファーマ
- 专利权人： Ltt Bio-Pharma Co Ltd,株式会社Lttバイオファーマ
- 当前专利权人： Ltt Bio-Pharma Co Ltd,株式会社Ｌｔｔバイオファーマ
- 优先权： JP2004205842 2004-07-13
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; A61K9/10 ; A61K9/14 ; A61K31/711 ; A61K47/02 ; A61K47/04 ; A61K47/34 ; A61K47/36 ; A61K47/42 ; A61K48/00 ; A61P17/00 ; A61P35/00 ; A61P37/02 ; A61P37/08 ; C12N15/09
摘要：
PROBLEM TO BE SOLVED: To provide an external preparation and an injection each containing a highly absorbable nucleic acid and having an effect enabling percutaneous or mucosal nucleic acid absorption hitherto sufficiently not been achieved, without a viral carrier.
SOLUTION: The subject nano particle is produced by non-covalently covering the periphery of a complex of a nucleic acid with a monovalent to trivalent basic salt and a divalent or trivalent metal salt or a cationic polymer, with an ionic functional group-having hydrophilic polymer, and a method for producing the same is also provided. A skin or mucosa application type external agent and an injection each containing the nano particles.
COPYRIGHT: (C)2006,JPO&NCIPI
SOLUTION: The subject nano particle is produced by non-covalently covering the periphery of a complex of a nucleic acid with a monovalent to trivalent basic salt and a divalent or trivalent metal salt or a cationic polymer, with an ionic functional group-having hydrophilic polymer, and a method for producing the same is also provided. A skin or mucosa application type external agent and an injection each containing the nano particles.
COPYRIGHT: (C)2006,JPO&NCIPI
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