Cold welding method, joint structure, and hermetically sealed containment device is provided. The method includes providing a first substrate having at least one first joint structure comprising a first mating surface including a first metal, comprising a second mating surface including a second metal providing a second substrate having at least one second joint structure, and the joint surface, of one or more at the interface, the bonding surface of the first metal and the second metal the metal between - an amount effective to form a metal bond, locally deformed, in order to shear, the combined at least one first joint structure and the at least one second joint structure comprising compressing. Overlapped portion of the bonding surface is to replace the surface contaminants is effective to promote intimate contact between the joining surfaces without heat input. Hermetically sealed devices, drug formulations can include a biosensor or MEMS device.