发明专利
JP2009256241A Bioactive protein-containing nanoparticle composition and method for producing the same
审中-公开
含有生物活性蛋白的纳米材料组合物及其制造方法
- 专利标题： Bioactive protein-containing nanoparticle composition and method for producing the same
- 专利标题（中）： 含有生物活性蛋白的纳米材料组合物及其制造方法
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申请号： JP2008107172申请日： 2008-04-16
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公开(公告)号： JP2009256241A公开(公告)日： 2009-11-05
- 发明人: MATSUMOTO TAKESHI
- 申请人： Galenisearch Laboratories Inc , Ltt Bio-Pharma Co Ltd , ガレニサーチ株式会社 , 株式会社Lttバイオファーマ
- 专利权人： Galenisearch Laboratories Inc,Ltt Bio-Pharma Co Ltd,ガレニサーチ株式会社,株式会社Lttバイオファーマ
- 当前专利权人： Galenisearch Laboratories Inc,Ltt Bio-Pharma Co Ltd,ガレニサーチ株式会社,株式会社Ｌｔｔバイオファーマ
- 优先权： JP2008107172 2008-04-16
- 主分类号： A61K47/02
- IPC分类号： A61K47/02 ; A61K9/14 ; A61K47/04 ; A61K47/26
摘要：
PROBLEM TO BE SOLVED: To provide a sustained-release composition that does not cause abnormal response at an administration site and maintains persistent activity of the contained bioactive protein or peptide when a predetermined amount of a bioactive protein or peptide is administered.
SOLUTION: The bioactive protein-containing nanoparticle composition comprises a bioactive protein or peptide, a water-soluble carbonate, a water-soluble phosphate and a water-soluble zinc salt with one another to form nanoparticle precipitates. The water-soluble zinc salt is added such that the compositional ratio of bioactive protein: the water-soluble zinc salt in a weight ratio is in the range of 1:0.2-1:3.5. The bioactive protein or peptide is G-CSF, hGH, interferon, erythropoietin or midkine.
COPYRIGHT: (C)2010,JPO&INPIT
SOLUTION: The bioactive protein-containing nanoparticle composition comprises a bioactive protein or peptide, a water-soluble carbonate, a water-soluble phosphate and a water-soluble zinc salt with one another to form nanoparticle precipitates. The water-soluble zinc salt is added such that the compositional ratio of bioactive protein: the water-soluble zinc salt in a weight ratio is in the range of 1:0.2-1:3.5. The bioactive protein or peptide is G-CSF, hGH, interferon, erythropoietin or midkine.
COPYRIGHT: (C)2010,JPO&INPIT
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