发明专利
JP2010222364A Use of cytokine-producing lactococcus strain to treat colitis 审中-公开
使用细胞因子生产乳杆菌菌株进行处理

Use of cytokine-producing lactococcus strain to treat colitis
摘要:
PROBLEM TO BE SOLVED: To provide an administration strategy for the delivery at the intestinal mucosa of cytokines or cytokine antagonists, preferably of acid sensitive anti-inflammatory agents, such as IL10 and/or soluble TNF receptor via the oral route.
SOLUTION: There is disclosed an inoculation with a suspension of recombinant cells using gram-positive bacteria such as Bacillus Subtilis, Streptococcus gordonii, Staphylococcus xylosus, or Lactobacillus species which has been engineered to produce the respective proteins such as cytokines or cytokine antagonists.
COPYRIGHT: (C)2011,JPO&INPIT
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