发明专利
- 专利标题： Immunogenic composition and method
- 专利标题（中）： 免疫组化和方法
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申请号： JP2011154426申请日： 2011-07-13
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公开(公告)号： JP2011251979A公开(公告)日： 2011-12-15
- 发明人: ELDRIDGE JOHN H , ISRAEL ZIMRA R , EGAN MICHAEL A , UDEM STEPHEN A
- 申请人： Wyeth Llc , ワイス・エルエルシー
- 专利权人： Wyeth Llc,ワイス・エルエルシー
- 当前专利权人： Wyeth Llc,ワイス・エルエルシー
- 优先权： US45787603 2003-03-26; US54673304 2004-02-23
- 主分类号： A61K39/205
- IPC分类号： A61K39/205 ; A61K9/00 ; A61K38/00 ; A61K39/00 ; A61K39/21 ; A61P31/04 ; A61P31/10 ; A61P31/12 ; A61P33/00 ; A61P35/00 ; A61P37/04 ; A61P37/08 ; A61P43/00 ; C12N15/09 ; C12N15/86
摘要：
PROBLEM TO BE SOLVED: To provide a method for inducing an antigen-specific immune response in a mammalian subject.SOLUTION: The method includes steps of administering to the subject an effective amount of a first composition comprising a DNA plasmid comprising a DNA sequence encoding the antigen under the control of regulatory sequences directing expression thereof in a mammalian or vertebrate cell. The method also includes administering to the subject an effective amount of a second composition comprising a recombinant vesicular stomatitis virus (rVSV) comprising a nucleic acid sequence encoding the antigen under the control of regulatory sequences directing expression thereof in the mammalian or vertebrate cell. The rVSV in the second composition is in one embodiment replication competent.
公开/授权文献
- JP5635950B2 免疫原性組成物および方法 公开/授权日：2014-12-03
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