本发明涉及一种治疗血管功能障碍，减少缺血性疼痛和/或治疗血管疾病的方法，包括向需要这种治疗的患者施用治疗有效量的膜联蛋白A5或其功能类似物或变体。 血管功能障碍，缺血性疼痛和/或血管疾病可能与内皮介导的血管扩张受损，eNOS活性降低和/或NO生物利用度降低有关。 患者可能患有选自心绞痛，缺血性心脏病，外周动脉疾病，收缩期高血压，偏头痛，2型糖尿病和勃起功能障碍的疾病。

The present invention provides Annexin A5 or a functional analogue of a therapeutically effective amount, or a variant thereof, comprising administering to a patient in need of such treatment, the treatment of vascular dysfunction, reduced ischemic pain, and / or to a method for the treatment of vascular disease. Vascular dysfunction, ischemic pain, and / or vascular disease, damage to the endothelium mediated expansion, decreased eNOS activity, and may be related to decrease in / or NO bioavailability. Patients, angina, ischemic heart disease, peripheral artery disease, systolic hypertension, may have been suffering from migraine, type 2 diabetes and diseases which are selected from the erectile dysfunction.