The present invention is, inter alia, antibodies or other targeting agents (e.g., targeting moiety) are linkers (e.g., non-cleavable linker) is linked to the drug via relates extracellular drug conjugate (EDC). These complexes, in the treatment of diseases, and / or as a means for evaluation of a biological system, are useful. In various embodiments, the present invention, a therapeutic agent selectively relates to a novel technique for (for example, antigen) delivery, antibody drug conjugate to use the target drug (ADC), as well as new other drug conjugate provides classification, it may be referred to as extracellular targeted drug conjugate (EDC).