The present invention, for imparting and / or enhancing an immune response through cell immunotherapy, nucleic acids, vectors, and provides a host cell, methods, and compositions, the cell immunotherapy, for example, inducible promoters under the control of a genetically modified to express a chimeric receptor, performed by adoptively transferred alone or in combination with CD4 + ^T cells CD8 ⁺ central memory T cells. In some embodiments, the genetically modified host cell is under the control of promoter induction by drugs, polynucleotide encoding a chimeric antigen receptor comprising a ligand binding domain, a polynucleotide comprising a spacer region, a transmembrane comprising a nucleic acid comprising a polynucleotide comprising a polynucleotide, and intracellular signaling domain, including the domain. By controlling the expression of said chimeric receptor can be switched on / off the expression of the receptor according to the patient's condition. How to use pharmaceutical preparations produced by the method of the present invention, and the pharmaceutical formulation are also encompassed by the present invention.