Method for verifying the validity of quantification of biomarkers, wherein the biomarkers are quantified using quantitative techniques of the selected type, and determining a plurality of biomarker values, each biomarker values, wherein It represents at least one corresponding value derived from the measured values ​​or measured values ​​for the biomarker in a biological subject, and, at least in part the concentration of the biomarker in samples taken from the subject shown, the determining at least one control value by determining a combination of biomarker values, comparing each reference value with each of the control reference, and using the result of the comparison, the biomarker values the method comprising determining whether it is reasonable.