发明专利
- 专利标题： Preparation of 2,2-dimethyl-5-hydroxythiazolidine derivative
- 专利标题（中）： 2,2-二甲基-5-羟基噻唑啉衍生物的制备
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申请号： JP4876983申请日： 1983-03-25
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公开(公告)号： JPS59175478A公开(公告)日： 1984-10-04
- 发明人: ANDOU WATARU , TAMURA YOSHIHARU
- 申请人： Nippon Rikagaku Yakuhin Kk
- 专利权人： Nippon Rikagaku Yakuhin Kk
- 当前专利权人： Nippon Rikagaku Yakuhin Kk
- 优先权： JP4876983 1983-03-25
- 主分类号： C07D277/06
- IPC分类号： C07D277/06 ; C07B41/02 ; C07D501/08
摘要：
PURPOSE: To obtain the titled compound useful as an intermediate for synthesizing caphalosporin, β-lactam antibiotic, by one process simply and easily, by oxidizng a 2,2-dimethylthiazolidine derivative as a raw material with oxygen in the presence of a photosensitizer.
CONSTITUTION: A 2,2-dimethylthiazolidine derivative shown by the formula I (R
1 is H, or lower alkyl; R
2 is amino-protecting group) is oxidized with oxygen in the presence of a photosensitizer in a polar solvent such as methanol, ethanol, acetonitrile, etc. to give a compound shown by the formula II. Preferably Rose Bengale, or methylene blue having good solubility in the polar solvent used in the above-mentioned reaction is used as the photosensitizer. Halogen-, tungsten-, sodium-lamp or mercury vapor lamp is used as a light irradiation lamp. An amount of the photosensitizer added is about 0.5W1wt% based on the raw material compound. The reaction is advanced smoothly by adding DMSO to it.
COPYRIGHT: (C)1984,JPO&Japio
CONSTITUTION: A 2,2-dimethylthiazolidine derivative shown by the formula I (R
1 is H, or lower alkyl; R
2 is amino-protecting group) is oxidized with oxygen in the presence of a photosensitizer in a polar solvent such as methanol, ethanol, acetonitrile, etc. to give a compound shown by the formula II. Preferably Rose Bengale, or methylene blue having good solubility in the polar solvent used in the above-mentioned reaction is used as the photosensitizer. Halogen-, tungsten-, sodium-lamp or mercury vapor lamp is used as a light irradiation lamp. An amount of the photosensitizer added is about 0.5W1wt% based on the raw material compound. The reaction is advanced smoothly by adding DMSO to it.
COPYRIGHT: (C)1984,JPO&Japio
公开/授权文献
- JPS6245230B2 公开/授权日：1987-09-25
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