Invention Patent
- Patent Title: Novel azulene derivative and its use
- Patent Title (中): 新亚利桑那衍生物及其使用
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Application No.: JP21812384Application Date: 1984-10-17
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Publication No.: JPS6197238APublication Date: 1986-05-15
- Inventor: YASUNAMI MASABUMI , TAKASE KAHEI , SHINSHI AKIRA , MIMURA TORU , TORII KUNIO , KOBAYASHI TAKAAKI , OKUTSU MASARU , MEGURO TAKASHI
- Applicant: Ajinomoto Co Inc
- Assignee: Ajinomoto Co Inc
- Current Assignee: Ajinomoto Co Inc
- Priority: JP21812384 1984-10-17
- Main IPC: A61K31/11
- IPC: A61K31/11 ; A61P3/06 ; C07C45/00 ; C07C47/445 ; C07C47/45 ; C07C67/00
Abstract:
NEW MATERIAL:The azulene derivative of formula I (R
1 and R
2 are H or 1W12C alkyl or alkenyl).
EXAMPLE: 3-Ethyl-7-isopropylazulene-1-aldehyde.
USE: An antihyperlipemia. It has no side effect and is useful for the prevention and remedy of hypertension, arteriosclerosis, etc.
PREPARATION: The compound of formula I can be prepared by introducing formyl group to the compound of formula II by the Vilsmeier reaction in dimethylformamide solvent in the presence of phosphorus oxychloride, distilling out the solvent from the reaction product under reduced pressure and passing the product through an alumina column to effect the separation and purification of the objective compound.
COPYRIGHT: (C)1986,JPO&Japio
1 and R
2 are H or 1W12C alkyl or alkenyl).
EXAMPLE: 3-Ethyl-7-isopropylazulene-1-aldehyde.
USE: An antihyperlipemia. It has no side effect and is useful for the prevention and remedy of hypertension, arteriosclerosis, etc.
PREPARATION: The compound of formula I can be prepared by introducing formyl group to the compound of formula II by the Vilsmeier reaction in dimethylformamide solvent in the presence of phosphorus oxychloride, distilling out the solvent from the reaction product under reduced pressure and passing the product through an alumina column to effect the separation and purification of the objective compound.
COPYRIGHT: (C)1986,JPO&Japio
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