- 专利标题: PRODUCTION OF ALPHA-ARYLCARBONYL DERIVATIVE
-
申请号: JP4083386申请日: 1986-02-26
-
公开(公告)号: JPS62198639A公开(公告)日: 1987-09-02
- 发明人: SAYO NOBORU , KUMOBAYASHI HIDENORI
- 申请人: TAKASAGO PERFUMERY CO LTD
- 专利权人: TAKASAGO PERFUMERY CO LTD
- 当前专利权人: TAKASAGO PERFUMERY CO LTD
- 优先权: JP4083386 1986-02-26
- 主分类号: C07D317/54
- IPC分类号: C07D317/54 ; B01J27/185 ; B01J31/00 ; B01J31/22 ; B01J31/28 ; C07B61/00 ; C07C45/00 ; C07C45/42 ; C07C45/45 ; C07C49/213 ; C07C49/255 ; C07C49/657 ; C07C67/00 ; C07C249/02 ; C07C251/16
摘要:
PURPOSE:To obtain the titled compound useful as an intermediate for pharmaceuticals, etc., economically, by condensing an aryl halide with an imine compound in the presence of a palladium compound, a tert-phosphine and a base and hydrolyzing the condensation product. CONSTITUTION:The objective compound of formula I useful also as an intermediate for food additives and perfumes is produced from an inexpensive raw material with simple procedure in high yield, by condensing (A) a compound of formula II (R1 and R2 are H, lower alkyl or lower alkoxy or R1 and R2 together form methylenedioxy; X is halogen) with (B) a compound of formula III (R3 and R4 are H or lower alkyl or together form a 5-7-membered cycloalkyl; R5 is lower alkyl or cyclohexyl) in the presence of a palladium compound of formula Pd(acac)2 (acac is acetylacetonate), etc., a tert-phosphine of formula V, etc., and a base such as sodium t-butyrate and hydrolyzing the condensation product.
公开/授权文献
- JPH0457659B2 公开/授权日:1992-09-14
信息查询