The present invention is filled with a solvent which dissolves the sparingly soluble medicinal ingredient high stability, and it is an object to provide a hard capsule which is excellent in mechanical strength under low humidity environment.
The present invention, (A) the presence of a polyvinyl alcohol and / or a derivative thereof, the general formula [1]
_{H 2 C = C (R 1} ) -COOR 2 [1]
Wherein, R ₁ represents a hydrogen atom or a methyl group, R ₂ represents an alkyl group having a hydrogen atom or 1 to 4 carbon atoms. ]
In at least one polymerizable vinyl monomer to the polymerization or copolymerization polymer or copolymer represented, and,
(B) (B-1) a polyhydric alcohol, (B-2) an ester of a polyhydric alcohol and a carboxylic acid having 1 to 5 carbon atoms, and (B-3) a polycarboxylic acid with a carbon number 1-5 alcohol esters, hard capsule having a coating comprising at least one compound selected from the group consisting of provided with.
The term capsule has an excellent mechanical strength, without impairing the low moisture resistance, has excellent physical stability even when filled with poorly soluble drug dissolution solvent.