本发明中，尔克有关的疾病，如疼痛，瘙痒，下尿路疾病，哮喘，过敏性鼻炎，在疾病的预防和/或治疗诸如炎性肠病或查加斯病，具有尔克抑制活性 化合物提供的试剂作为活性成分。 通式（I）（其中所有符号表示。含义如说明书中所描述的符号相同），通过，其盐，其N-氧化物，其溶剂化物或其前药表示的化合物， 痛，瘙痒，下尿路疾病，哮喘，过敏性鼻炎，在预防和/或治疗的疾病，例如炎症性肠疾病或查加斯病，并且是作为具有尔克抑制活性的药物成分是有用的。

The present invention, Trk related diseases, such as pain, pruritus, lower urinary tract disorders, asthma, allergic rhinitis, in the prevention and / or treatment of diseases such as inflammatory bowel disease or Chagas disease, has a Trk inhibitory activity the compound to provide the drug as an active ingredient. The general formula (I)

(Wherein all symbols represent. The same meanings as symbols described in the specification), a compound represented by, a salt thereof, N- oxide thereof, a solvate thereof or a prodrug thereof, are pain, pruritus disease, lower urinary tract disorders, asthma, allergic rhinitis, in the prevention and / or treatment of diseases such as inflammatory bowel disease or Chagas' disease, and is useful as a pharmaceutical ingredient having a Trk inhibitory activity.