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发明授权
KR101753137B1 4-((치환 페닐)디플루오로메틸)페녹시 카르복실산 유도체 및 그 제조방법과 사용방법 有权
4 - （（取代苯基）二氟甲基）苯氧基羧酸衍生物及其制备和应用

4-((치환 페닐)디플루오로메틸)페녹시 카르복실산 유도체 및 그 제조방법과 사용방법
摘要：
4-((치환페닐)디플루오로메틸)페녹시카르복실산유도체와그 제조방법및 사용방법을개시한다. 더구체적으로, 본발명은화학식(I)로표시되는구조를갖고상세한설명에서정의된바와같은화합물에관한것이다. 본발명의화합물은 PPAR 길항제로사용될수 있으며, 혈장내총 콜레스테롤(TC), 트리글리세라이드(TG) 및저밀도지질단백질콜레스테롤(LDL-C)의농도를감소시키는데비교적강력한효과를나타낸다. 따라서, 본발명의화합물은고지혈증또는고지혈증에의해야기되는심혈관및 뇌혈관계질환, 예컨대, 당뇨, 죽상경화증, 뇌졸증및 관상동맥형심장질환등을치료하거나예방하기위한약물의제조에이용할수 있다. 본발명은또한화학식(I)로표시되는화합물의제조를위한신규의중간화합물, 및그 제조방법에관한것이다.(I)
摘要（中）：

4 - （（取代苯基）二氟甲基）苯氧基羧酸衍生物及其制备方法和使用方法。 更具体地说，本发明涉及具有由式（I）表示的结构且如详述中所定义的化合物。 本发明的化合物可以被用作PPAR拮抗剂，naechong血浆胆固醇（TC），降低甘油三脂（TG）和低密度脂蛋白胆固醇（LDL-C）示出了比较强的效果的浓度。 因此，本发明的化合物可以用在心血管和脑血管疾病引起的高脂血症，血脂异常或，例如，糖尿病，动脉粥样硬化，中风和冠心病心脏疾病和类型的治疗或预防的药物的制造中使用。 本发明还涉及用于制备式（I）化合物的新型中间体化合物，

摘要（英）：

4 discloses a phenoxy-carboxylic acid derivatives and a method for manufacturing the same and method of use ((2-substituted phenyl) difluoro). More particularly, the invention relates to compounds as defined in the detailed description has a structure represented by the general formula (I). The compounds of the present invention may be used as a PPAR antagonist, to reduce the concentration of plasma total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) shows a relatively strong effect. Thus compounds of the invention can be used for the manufacture of a medicament for the treatment or prevention of cardiovascular and cerebrovascular disease caused by hyperlipidemia, or dyslipidemia, e.g., diabetes, atherosclerosis, stroke and coronary heart disease and type. The invention also relates to intermediate compounds, and a method of manufacturing the novel for the production of a compound represented by the formula (I).

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