Invention Publication
KR1020080059681A 신규한 만델산 유도체 및 트롬빈 억제제로서 이들의 용도 失效 - Ended
新型苹果酸衍生物及其作为硫蛋白抑制剂的用途

  • Patent Title: 신규한 만델산 유도체 및 트롬빈 억제제로서 이들의 용도
  • Patent Title (English): New mandelic acid derivatives and their use as thrombin inhibitors
  • Patent Title (中): 新型苹果酸衍生物及其作为硫蛋白抑制剂的用途
  • Application No.: KR1020087014404
    Application Date: 2001-11-30
  • Publication No.: KR1020080059681A
    Publication Date: 2008-06-30
  • Inventor: 인하르트토드요한슨앤더스스벤손아른
  • Applicant: 아스트라제네카 아베
  • Applicant Address: SE-*** ** Sodertalje, Sweden
  • Assignee: 아스트라제네카 아베
  • Current Assignee: 아스트라제네카 아베
  • Current Assignee Address: SE-*** ** Sodertalje, Sweden
  • Agent 김성기; 김진회
  • Priority: SE0004458-6 2000-12-01; SE0100965-3 2001-03-19; SE0101239-2 2001-04-06; SE0102921-4 2001-08-30
  • International Application: PCT/SE2001/002657 2001-11-30
  • International Announcement: WO2002044145 2002-06-06
  • Main IPC: C07D205/04
  • IPC: C07D205/04 C07D207/10 A61K31/397 A61P7/02
신규한 만델산 유도체 및 트롬빈 억제제로서 이들의 용도
Abstract:
There is provided a compound of formula (I) wherein Ra, R1, R2, Y and R3 have meanings given in the description and pharmaceutically-acceptable derivatives (including prodrugs) thereof, which compounds and derivatives are useful as, or are useful as prodrugs of, competitive inhibitors of trypsin-like proteases, such as thrombin, and thus, in particular, in the treatment of conditions where inhibition of thrombin is required (e.g. thrombosis) or as anticoagulants.
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