The compositions and methods for raising the nitric oxide level in acute are disclosed herein in the object. In one instance, the composition NOS dependent source of nitric oxide in an effective amount; NOS independent source of nitric oxide in an effective amount; And the effect may include a bone marrow cell-type peroxidase inhibitor of the amount; Wherein the composition is in excess of the levels provided by the available supply of nitric oxide in the above nitric oxide levels in the object to the object of administration of the composition up to acute. The method for treating an object for a disease or disorder responsive to the nitric oxide therapy also been proposed, and to increase the biosynthesis of nitric oxide at the same time, increasing the nitrate / nitrite levels and, and on the object by inhibiting the bone marrow cell-type peroxidase activity include raising the level of nitric oxide in acute.