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KR20210033004A RTEL1의 발현을 조절하기 위한 올리고뉴클레오티드 审中-公开

  • 专利标题： RTEL1의 발현을 조절하기 위한 올리고뉴클레오티드
  • 专利标题（英）： KR20210033004A - Oligonucleotides for regulating the expression of RTEL1
  • 申请号： KR20217004297
    申请日： 2019-07-11
  • 公开(公告)号： KR20210033004A
    公开(公告)日： 2021-03-25
  • 优先权： EP18183477 2018-07-13
  • 主分类号： C12N15/113
  • IPC分类号： C12N15/113 ;  A61K31/7088 ;  A61P31/12
RTEL1의 발현을 조절하기 위한 올리고뉴클레오티드
摘要：
본원발명은 HBV 감염, 특히만성 HBV 감염의치료에서이용을위한 RTEL1 저해제에관계한다. 본원발명은특히, cccDNA, 예컨대 HBV cccDNA를불안정화하기위한 RTEL1 저해제의용도에관계한다. 본원발명은또한, RTEL1에상보적이고 RTEL1 mRNA를감소시킬수 있는안티센스올리고뉴클레오티드에관계한다. 제약학적조성물및 HBV 감염의치료및/또는예방에서이의용도역시본원발명내에포함된다.
摘要（英）：

The present invention relates to RTEL1 inhibitors for use in the treatment of HBV infections, particularly chronic HBV infections. The present invention particularly relates to the use of RTEL1 inhibitors to destabilize cccDNA, such as HBV cccDNA. The present invention also relates to antisense oligonucleotides that are complementary to RTEL1 and capable of reducing RTEL1 mRNA. Pharmaceutical compositions and their use in the treatment and/or prevention of HBV infection are also included within the present invention.

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