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发明授权
KR102237737B1 도네페질 함유 서방출성 PLGA 미립구의 제조방법 有权

도네페질 함유 서방출성 PLGA 미립구의 제조방법
摘要：
본발명은도네페질함유서방출성 PLGA 미립구의제조방법에관한것으로, 구체적으로, 도네페질함유서방출성 PLGA 미립구의제조방법에있어서, i) 도네페질또는이의약제학적으로허용되는염, PLGA(Poly(lactic-co-glycolic acid) 및유기용매를포함하는분산상을미세유체칩에주입하여미립구액적을제조하는단계; 및 ii) 상기미립구액적을, 계면활성제가포함된 15 내지 25℃의수상에분산시키는단계를포함하는것인도네페질함유서방출성 PLGA 미립구의제조방법에관한것이다. 본발명의도네페질함유서방출성 PLGA 미립구의제조방법은고함량의도네페질을함유하면서제조재현성이높은서방출성미립구를제조할수 있는바, 안전하면서안정적인치료제제조등에이용될수 있다.
摘要（英）：

The present invention relates to a method for producing sustained-release PLGA microspheres containing donepezil, and specifically, in a method for producing sustained-release PLGA microspheres containing donepezil, i) donepezil or a pharmaceutically acceptable salt thereof, PLGA (Poly ( lactic-co-glycolic acid) and injecting a dispersed phase containing an organic solvent into a microfluidic chip to prepare microsphere droplets; And ii) dispersing the microsphere droplets in an aqueous phase of 15 to 25°C containing a surfactant. It relates to a method for producing sustained-release PLGA microspheres containing donepezil comprising the step.
The manufacturing method of the sustained-release PLGA microspheres containing donepezil of the present invention can produce sustained-release microspheres containing a high content of donepezil and high production reproducibility, and thus can be used for the production of safe and stable therapeutic agents.

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