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KR102239138B1 표적 항원에 대한 면역응답을 유도하는 항원 결합 분자 有权

표적 항원에 대한 면역응답을 유도하는 항원 결합 분자
摘要：
본발명자들은이온농도의조건에따라항원에대한결합활성이변화되는항원결합도메인및 pH 중성역의조건하에서 FcRn에대한결합활성을갖는 FcRn 결합도메인을포함하는항원결합분자가투여된생체에있어서, 당해항원에대한면역응답이유도되고있는것을발견하였다. 또한본 발명자들은이온농도의조건에따라항원에대한결합활성이변화되는항원결합도메인및 pH 중성역의조건하에서 FcRn에대한결합활성을갖는 FcRn 결합도메인을포함하는항원결합분자가투여된생체에있어서, 당해항원에대한면역응답이유도되고있는동시에당해항원결합분자가결합하는항원을발현하는외래생물종이나암세포등에대한상해작용또는증식억제작용을겸비하는것을발견하였다.
摘要（英）：

In a living body to which an antigen-binding molecule comprising an antigen-binding domain whose antigen-binding activity is changed depending on the ion concentration condition and an FcRn-binding domain having FcRn-binding activity under the conditions of a neutral pH range, It was found that an immune response to the antigen is being induced. In addition, the present inventors in a living body to which an antigen-binding molecule comprising an antigen-binding domain whose antigen-binding activity changes depending on the ion concentration and an FcRn-binding domain having FcRn-binding activity under the conditions of a neutral pH range , It was found that an immune response to the antigen was induced, and at the same time, the antigen-binding molecule had both an injury or proliferation inhibitory action against foreign species or cancer cells that express the antigen to which the antigen-binding molecule binds.

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