- 专利标题： Amide-substituted heterocyclic compounds useful as modulators of IL-12, IL-23 and/or IFN alpha responses
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申请号： US15289437申请日： 2016-10-10
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公开(公告)号： US10000480B2公开(公告)日： 2018-06-19
- 发明人: Ryan M. Moslin , David S. Weinstein , Stephen T. Wrobleski , John S. Tokarski , Amit Kumar , Douglas G. Batt , Shuqun Lin , Chunjian Liu , Steven H. Spergel , Yanlei Zhang , Qingjie Liu
- 申请人： BRISTOL-MYERS SQUIBB COMPANY
- 申请人地址： US NJ Princeton
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： US NJ Princeton
- 代理商 Elliott Korsen
- 主分类号： C07D417/14
- IPC分类号： C07D417/14 ; C07D403/12 ; C07D401/14 ; C07D413/14 ; C07D401/12 ; C07D237/24 ; C07D403/14 ; C07D413/12 ; C07D417/12 ; C07B59/00
摘要：
Compounds having the following formula I: or a stereoisomer or pharmaceutically-acceptable salt thereof, where R1, R2, R3, R4, and R5 are as defined herein, are useful in the modulation of IL-12, IL-23 and/or IFNα, by acting on Tyk-2 to cause signal transduction inhibition.
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