Invention Grant
- Patent Title: Inhibitors of the renal outer medullary potassim channel
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Application No.: US15101467Application Date: 2014-12-16
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Publication No.: US10000484B2Publication Date: 2018-06-19
- Inventor: Harry Chobanian , Barbara Pio , Yan Guo , Fa-Xiang Ding , Shuzhi Dong , Shawn P. Walsh , Jinlong Jiang , Dooseop Kim
- Applicant: MERCK SHARP & DOHME CORP. , Harry Chobanian , Barbara Pio , Yan Guo , Fa-Xiang Ding , Shuzhi Dong , Shawn P. Walsh , Jinlong Jiang , Dooseop Kim
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Sarah Hooson; Catherine D. Fitch
- International Application: PCT/US2014/070441 WO 20141216
- International Announcement: WO2015/095097 WO 20150625
- Main IPC: A61K31/4355
- IPC: A61K31/4355 ; A61K31/437 ; A61K31/4985 ; A61K31/519 ; A61K31/55 ; C07D471/04 ; C07D487/04 ; C07D498/04 ; A61K31/401 ; A61K31/4178 ; A61K31/424 ; A61K31/4422 ; A61K31/496 ; A61K31/4965 ; A61K31/585 ; A61K45/06
Abstract:
The present invention provides compounds of Formula (I) (Formula (I)) including pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
Public/Granted literature
- US20160304515A1 INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIM CHANNEL Public/Granted day:2016-10-20
Information query
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