Invention Grant
- Patent Title: Polypeptides with permease activity
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Application No.: US14895742Application Date: 2014-06-04
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Publication No.: US10000537B2Publication Date: 2018-06-19
- Inventor: Paul Klaassen , Paulus Petrus De Waal , Rene Marcel De Jong , Arnold Jacob Mattieu Driessen , Jeroen Gerben Nijland , Hyun Yong Shin
- Applicant: DSM IP ASSETS B.V.
- Applicant Address: NL Heerlen
- Assignee: DSM IP ASSETS B.V.
- Current Assignee: DSM IP ASSETS B.V.
- Current Assignee Address: NL Heerlen
- Agency: McBee Moore Woodward & Vanik IP, LLC
- Agent Susan McBee; Chester Moore
- Priority: EP13170644 20130605; EP13170646 20130605; EP13170648 20130605; EP13197988 20131218; EP14160772 20140319; EP14164270 20140410
- International Application: PCT/EP2014/061632 WO 20140604
- International Announcement: WO2014/195376 WO 20141211
- Main IPC: C12P21/06
- IPC: C12P21/06 ; C12P19/34 ; C12N15/00 ; C12N1/00 ; C07H21/04 ; C07K1/00 ; C07K14/395 ; C12P19/02
Abstract:
The invention relates to a polypeptide having one or more substitution at a position corresponding to position 339 or 376 of SEQ ID NO: 59, wherein the polypeptide is a member of the Major Facilitator Superfamily (MFS). In an embodiment, the substitution is at position corresponding to 376 and wherein the amino acid at that position is replaced by an amino acid that has a van der Waals volume of 80 to 138 Å3 and a side chain hydrophobicity of 10 to 100 ΔtR.
Public/Granted literature
- US20160122400A1 POLYPEPTIDES WITH PERMEASE ACTIVITY Public/Granted day:2016-05-05
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