A system and method are provided for medical imaging that includes acquiring, during a common imaging acquisition process, rotational, x-ray volume image data and x-ray tomosynthesis image data from a subject. The method includes reconstructing a time-resolved three-dimensional (3D) image volume from the rotational, x-ray volume image data and producing a four-dimensional (4D) image series of the subject with resolved overlapping features by selectively combining the time-resolved 3D image volume and the x-ray tomosynthesis imaging data.