- 专利标题： Small molecule ice recrystallization inhibitors and methods of use thereof
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申请号： US14848942申请日： 2015-09-09
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公开(公告)号： US10004222B2公开(公告)日： 2018-06-26
- 发明人: Robert Ben , Chantelle J. Capicciotti , Jennie Briard
- 申请人： THE UNIVERSITY OF OTTAWA
- 申请人地址： CA Ottawa
- 专利权人： THE UNIVERSITY OF OTTAWA
- 当前专利权人： THE UNIVERSITY OF OTTAWA
- 当前专利权人地址： CA Ottawa
- 代理机构： Harness, Dickey & Pierce, P.L.C.
- 主分类号： A01N1/02
- IPC分类号： A01N1/02
摘要：
Ice recrystallization inhibitor (IRI) compounds and methods for cryopreserving umbilical cord blood are provided. The compounds are unsubstituted, mono-substituted, or di-substituted aryl-aldonamides. The methods include fractionating whole umbilical cord blood to generate a fraction comprising hematopoietic stem cells, mixing the hematopoietic stem cells with at least one IRI compound to form an IRI suspension, and freezing the IRI suspension.
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